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目的观察活血Ⅰ号胶囊对2级高血压病血栓前状态的影响。方法152例2级高血压病患者随机分为左旋氨氯地平组、阿司匹林组、活血Ⅰ号组,分别予以口服左旋氨氯地平片、左旋氨氯地平片+肠溶阿司匹林片、左旋氨氯地平+活血Ⅰ号胶囊8周,观察治疗前后血压、一氧化氮、血管性假血友病因子、活化血小板颗粒膜蛋白及纤维蛋白原水平的变化。结果2级高血压病患者治疗前一氧化氮水平较健康成人明显下降(P<0.05),而血管性假血友病因子、活化血小板颗粒膜蛋白和纤维蛋白原水平均明显升高(P均<0.05);经治疗后,三组患者血浆一氧化氮水平均较治疗前升高(P<0.05),且活血Ⅰ号组升高最为明显(P<0.05),血管性假血友病因子、活化血小板颗粒膜蛋白和纤维蛋白原水平均较治疗前降低(P<0.05),其中血管性假血友病因子、活化血小板颗粒膜蛋白水平在左旋氨氯地平组与阿司匹林组之间差异无显著性(P>0.05),但活血Ⅰ号组较左旋氨氯地平组和阿司匹林组更低(P<0.05);阿司匹林组与活血Ⅰ号组中纤维蛋白原水平均明显低于左旋氨氯地平组(P<0.05),但活血Ⅰ号组更低(P<0.05)。结论活血Ⅰ号胶囊和氨氯地平通过保护血管内皮、稳定血小板功能治疗高血压血栓前状态。
Objective To observe the effect of Huoxue capsule Ⅰ on the prethrombotic state of grade 2 essential hypertension. Methods A total of 152 patients with Grade 2 Hypertension were randomly divided into L-amlodipine group, Aspirin group and Huoxue I group, and received oral levamlodipine tablets, levamlodipine tablets, enteric-coated aspirin tablets, levamlodipine + Huoxue Ⅰ capsule for 8 weeks. The changes of blood pressure, nitric oxide, von willebrand factor, activated granule membrane protein and fibrinogen were observed before and after treatment. Results The levels of nitric oxide in patients with grade 2 hypertension before treatment were significantly lower than those in healthy adults (P <0.05), but the levels of vWF, granulosa membrane protein and fibrinogen were significantly increased (all P < 0.05). After treatment, the levels of plasma nitric oxide in all three groups were significantly higher than those before treatment (P <0.05), and those in Huoxue I group were the most significant (P <0.05). The levels of von Willebrand factor, The levels of activated platelet granule membrane protein and fibrinogen were significantly lower than those before treatment (P <0.05). There was no significant difference in the levels of von Willebrand factor and activated granule membrane protein between L-amlodipine group and aspirin group (P> 0.05). However, the levels of fibrinogen in aspirin group and Huoxue I group were lower than those in levamlodipine group and aspirin group (P <0.05) <0.05), but lower in Huoxue I group (P <0.05). Conclusion Huoxue Capsule and amlodipine can treat prethrombotic state of hypertension by protecting vascular endothelium and stabilizing platelet function.