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目的采用Meta分析方法,评价酪酸梭菌在治疗慢性胃炎及消化道溃疡伴幽门螺杆菌感染的临床效果及降低胃肠道反应的疗效。方法计算机检索Pubmed、中国知网、万方、维普等常用数据库中酪酸梭菌联合传统疗法(三联、四联疗法)与单独传统疗法治疗幽门螺杆菌感染的RCT研究,对符合纳入标准的RCT,由两位评价员按Cochrane系统评价的方法,独立进行资料提取、质量评价并交叉核对后,采用Rev Man 5.35软件进行Meta分析。分析幽门螺杆菌治疗有效率、根治率及不良反应发生率的合并RR值及发表偏倚。结果共9项RCT研究符合纳入标准,酪酸梭菌联合传统疗法与单独传统疗法相比,治疗有效率、根治率及不良反应发生率的合并RR值及95%CI分别为2.91(1.81~4.68)、3.52(2.49~4.97)和0.27(0.17~0.45)。结论酪酸梭菌联合传统疗法治疗慢性胃炎及消化道溃疡合并幽门螺杆菌的有效率、根治率及降低胃肠道不良反应的效果均优于单一传统疗法。
Objective To evaluate the clinical efficacy of Clostridium butyricum in the treatment of chronic gastritis and peptic ulcer with Helicobacter pylori infection and to reduce the gastrointestinal reaction by Meta analysis. Methods RCTs of H.pylori infection combined with C. butyricum and traditional therapy (triple therapy and quadruple therapy) and traditional therapy alone were searched by computer in Pubmed, China National Knowledge Infrastructure, Wanfang, Vipu and other commonly used databases. RCT, Two reviewers, based on the Cochrane systematic review, independently extracted data, assessed quality, and cross-checked them, using a meta-analysis of Rev Man 5.35 software. Analysis of Helicobacter pylori treatment efficiency, cure rate and the incidence of adverse reactions combined RR and publication bias. Results A total of 9 RCTs met the inclusion criteria. The combined RR and 95% CI of Clostridium butyricum plus conventional therapy compared with conventional therapy alone were 2.91 (1.81 ~ 4.68), respectively. , 3.52 (2.49 ~ 4.97) and 0.27 (0.17 ~ 0.45) respectively. Conclusions Clostridium butyricum combined with traditional therapy is superior to single conventional therapy in the treatment of chronic gastritis and peptic ulcer combined with Helicobacter pylori eradication rate, curative rate and gastrointestinal adverse reactions.