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异基因骨髓移植(Allogencic bone marrow trans-plantation,allo—BMT)能有效地根治各种急、慢性白血病。其复发率大大低于化疗,亦低于自体骨髓移植(Autologous bone marrow transplantation,ABMT)。allo—BMT的这种抗白血病作用并非完全归功于预处理过程的超大剂量化疗和/或放疗,且与输入的异体免疫活性细胞诱导的过继性免疫反应有关,这种免疫反应即可发挥移植物抗白血病效应(Graft versusleukemia,GVL)。1 动物及人类的GVL1.1 动物模型中的GVL Butturini及Sosmn分别对动物模型中的GVL作过详尽的综述。综合的资料表明动物模型中不仅存
Allogencic bone marrow trans-plantation (allo-BMT) can effectively cure various acute and chronic leukemias. The recurrence rate was significantly lower than chemotherapy, also lower than autologous bone marrow transplantation (Autologous bone marrow transplantation, ABMT). This anti-leukemic effect of allo-BMT is not entirely due to the ultra-high dose chemotherapy and / or radiotherapy of the pretreatment process and is associated with an adoptive immune response induced by the input of allogeneic immunocompetent cells that can function as a graft Anti-leukemia effect (Graft versus leukemia, GVL). GVL Butturini and Sosmn in Animal and Human GVL1.1 Animal Models The GVL in animal models were reviewed in detail. The comprehensive data shows that not only the animal model exists