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目的:探讨益气健脾方辅治对慢性阻塞性肺疾病(COPD)稳定期肺脾气虚型患者肺功能、运动耐量及安全性的影响。方法:选取COPD稳定期肺脾气虚型患者140例,随机分为观察组与对照组,每组70例。对照组予以COPD稳定期的常规处理措施,观察组在此基础上,辅以益气健脾方治疗。2组均治疗12周。于治疗前、治疗后分别比较2组患者的圣·乔治呼吸疾病问卷(SGRQ)调查评分、6 min步行距离(6MWT)、肺功能指标,包括第1秒用力呼气容积(FEVl)、第1秒用力呼吸气量占预计值的百分比(FEVl%)、血气分析,观察药物不良反应。结果:2组患者治疗前,SGRQ总分、6MWT比较,差异均无显著性意义(P>0.05);治疗后,2组患者SGRQ总分、6MWT均有不同程度的改善,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);治疗后观察组与对照组SGRQ总分、6MWT比较,差异有显著性意义(P<0.05)。2组患者治疗前Pa O2、Pa CO2、FEV1、FEV1%比较,差异均无显著性意义(P>0.05);治疗后,2组患者Pa O2、Pa CO2、FEV1、FEV1%均有不同程度的改善,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);治疗后观察组与对照组Pa O2、Pa CO2、FEV1、FEV1%比较,差异均有显著性意义(P<0.05)。结论:益气健脾方辅治COPD稳定期肺脾气虚型患者有效地缓解其呼吸困难症状,延缓肺功能恶化,提高运动耐量,其疗效优于单纯西药治疗。
Objective: To investigate the effects of Yiqi Jianpi Recipe on lung function, exercise tolerance and safety in patients with chronic obstructive pulmonary disease (COPD) with stable lung and spleen deficiency type. Methods: One hundred and fourteen patients with COPD in stable stage were selected and randomly divided into observation group and control group with 70 cases in each group. The control group was given routine treatment of COPD stable period, the observation group on this basis, supplemented with Yiqi Jianpi Fang treatment. The two groups were treated for 12 weeks. Before treatment and after treatment, the SGRQ survey scores, 6-minute walk distance (6MWT), lung function indexes including 1 second forced expiratory volume (FEV1), 1 Second, the percentage of forced breathing air volume (FEVl%), blood gas analysis, observation of adverse drug reactions. Results: There was no significant difference in SGRQ score and 6MWT before treatment between two groups (P> 0.05). After treatment, SGRQ score and 6MWT in both groups were improved to some extent. Compared with before treatment, (P <0.05, P <0.01). After treatment, SGRQ total score and 6MWT in observation group and control group were significantly different (P <0.05). PaO2, Pa CO2, FEV1, FEV1% before treatment in the two groups had no significant difference (P> 0.05); after treatment, PaO2, Pa CO2, FEV1, FEV1% (P <0.05, P <0.01). After treatment, PaO2, Pa CO2, FEV1 and FEV1% of the observation group and the control group were significantly different Significance (P <0.05). Conclusion: Yiqi Jianpi Decoction can effectively relieve the symptoms of dyspnea, retard the deterioration of lung function and improve the exercise tolerance in stable COPD patients with lung-spleen-qi-deficiency syndrome. The curative effect is superior to that of western medicine alone.