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目的:探讨恩丹西酮对于抗肿瘤药物引起的恶心、呕吐的疗效及其不良反应。方法:采用与国产恩丹西酮(枢丹)对照和自身对照。方法,对102例恶性肿瘤患者应用含有顺氯氨铂(80~100mg/m2)的化疗方案进行临床观察。结果:ODS组防治恶心d1~3有效率分别为86.2%,82.3%及80.4%,总有效率73.5%;防治呕吐d1~3有效率分别为89.2%,86.3%及88.2%,总有效率为84.3%;男性及中老年组有效率优于女性与青少年组(P<0.05);且不良反应轻微。结论:ODS是防治肿瘤化疗引起的恶心、呕吐的安全有效药物。
Objective: To investigate the efficacy and side effects of ondansetron on nausea and vomiting induced by antineoplastic agents. Methods: Domestic and ondansetron (Shuduan) control and self-control. Methods 102 patients with malignant tumor chemotherapy containing cisplatin (80 ~ 100mg / m2) for clinical observation. Results: The effective rates of d1 ~ 3 in preventing and treating nausea in ODS group were 86.2%, 82.3% and 80.4%, respectively, with a total effective rate of 73.5%. The effective rates of d1 ~ 3 in prevention and treatment of vomiting were 89.2%, 86.3% and 88.2% 84.3%. The effective rate of male and middle aged group was better than that of female and adolescent group (P <0.05), and the adverse reaction was slight. Conclusion: ODS is a safe and effective drug for prevention and treatment of nausea and vomiting caused by chemotherapy of tumor.