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目的探讨家栖鼠对抗凝血灭鼠剂的抗药性变化。方法按全国鼠类抗药性监测协作组统一方法,进行无选择性摄毒试验。结果经对清远市城区及所辖3个县城区内所捕获的155只褐家鼠、13只黄胸鼠、28只小家鼠进行抗药性监测,其抗性率分别为0.65%、0和50.00%,总平均摄药剂量分别为9.82、84.92和453.70mg/kg,按家栖鼠抗药性检验标准,小家鼠对第一代抗凝血剂杀鼠灵已形成抗药性种群,褐家鼠有抗药性个体产生。结论以小家鼠为优势种的场所,要考虑使用第二代抗凝血灭鼠剂;而以褐家鼠、黄胸鼠为主的场所,则可继续使用第一代抗凝血灭鼠剂,但应加强对灭鼠药物的敏感性监测,科学、合理用药。
Objective To investigate the resistance of domestic rats to anticoagulant rodenticides. Methods According to the unified method of the National Collaborating Group on Resistance Investigation of Rodents, a non-selective toxicity test was conducted. Results The drug resistance of 155 Rattus norvegicus, 13 Rattus flavipectus and 28 Mus musculus were captured in the urban areas of Qingyuan City and the three counties under the jurisdiction. The resistance rates were 0.65%, 0 and 50.00%, the total average dose was 9.82,84.92 and 453.70mg / kg, respectively, according to the standard test of drug resistance of Musca domestica, Mus musculus on the first generation of anticoagulant warfarin has formed resistant populations, brown home Murine resistant individuals develop. Conclusion The dominant species of Mus musculus is the place where the second generation of anticoagulant rodenticides should be considered. However, the first generation of anticoagulant rodenticides However, the sensitivity of rodent control drugs should be monitored, scientifically and rationally.