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目的观察纳洛酮治疗小儿病毒性脑炎(EN)的疗效。方法将52例病毒性脑炎患儿随机分成纳洛酮治疗组26例及利巴韦林对照组26例,治疗组给予纳络酮0.01～0.03mg/(kg·次),加入葡萄糖,每隔8h静脉滴注1次,连用10～14d为1个疗程;对照组给予利巴韦林10mg/(kg·d),2次/d,疗程为10～14d,两组患儿均接受病毒性脑炎的常规治疗,对对照组患儿的临床表现及治疗效果进行观察。结果纳洛酮治疗组疗效显著,在头痛、呕吐、抽搐、昏迷消失时间、退热时间及住院时间均优于对照组。后遗症发生率显著低于对照组。结论纳洛酮治疗病毒性脑炎有较显著的疗效。
Objective To observe the efficacy of naloxone in the treatment of pediatric viral encephalitis (EN). Methods 52 children with viral encephalitis were randomly divided into naloxone treatment group (n = 26) and ribavirin control group (n = 26). The treatment group was given naloxone 0.01-0.03 mg / (kg · d) The rabbits in the control group were treated with ribavirin 10 mg / (kg · d) twice daily for 10-14 days. The two groups of children received the virus Routine treatment of encephalitis, the control group of children with clinical manifestations and treatment were observed. Results Naloxone treatment group was significantly effective, headache, vomiting, convulsions, coma disappear time, antipyretic time and hospital stay were better than the control group. The incidence of sequelae was significantly lower than that of the control group. Conclusion Naloxone treatment of viral encephalitis has a more significant effect.