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给正常家兔和阿霉素性心肌病心衰家兔静脉注射谷酰多巴 (2 5和 10 0μg/kg· min) 6 0 min后 ,平均动脉压、心率和血浆多巴胺含量均无显著变化。两组动物血浆谷酰多巴的浓度类似 ,尿多巴胺排泌率和肾组织多巴胺含量均显著增加 ,其增加程度在心力衰竭组显著低于正常对照组。表明阿霉素性心肌病心衰家兔肾脏由谷酰多巴合成多巴胺的功能受损
The mean arterial pressure, heart rate and plasma dopamine level in rabbits with normal cardiomyopathy and doxorubicin-induced cardiomyopathy rabbits were intravenously injected with valproate (2.5 and 10 μg / kg · min) for 60 min . Two groups of animals, the concentration of plasma dopamine similar to the rate of urinary dopamine excretion and renal tissue dopamine were significantly increased, the extent of the increase in heart failure group was significantly lower than the normal control group. That doxorubicin cardiomyopathy heart failure rabbit kidneys dopamine synthesis by the function of dopamine impaired