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目的探讨美托洛尔治疗法洛四联症在手术麻醉过程中缺氧发作的疗效及安全性。方法分析18例法洛四联症手术患者的临床资料,均因手术中出现缺氧发作而静脉滴注美托洛尔治疗,观察美托洛尔缓解缺氧发作的疗效及不良反应。结果全组使用均有效,静脉滴注美托洛尔2min后患者心率下降、血氧饱和度回升,5min后血氧饱和度显著回升(P<0.05),而用药前后血压均无明显变化(P>0.05)。结论美托洛尔能有效缓解法洛四联症的缺氧发作。
Objective To investigate the efficacy and safety of metoprolol in the treatment of tetralogy of Fallot during hypoxia in surgical anesthesia. Methods The clinical data of 18 patients with tetralogy of Fallot were analyzed. Metoprolol was administered by intravenous infusion during hypoxia. The curative effect and adverse reactions of metoprolol on hypoxia were observed. Results All the patients were used effectively. After 2 minutes of intravenous infusion of metoprolol, heart rate decreased and oxygen saturation rose. After 5 minutes, blood oxygen saturation increased significantly (P <0.05), but there was no significant change in blood pressure before and after treatment (P > 0.05). Conclusion Metoprolol can effectively relieve the hypoxia in tetralogy of Fallot.