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本文采用免疫荧光及PAP法对11例尸检乙脑脑组织内乙脑病毒抗原进行定位研究,并结合组织学改变进行观察。结果发现9例脑神经细胞胞浆内免疫荧光及PAP阳性(重型2例、普通型7例),其中7例普通型阳性强于2例重型。进一步证实了乙脑病毒存在于大脑神经细胞胞浆内的学说,并认为造成脑组织的病理学改变是免疫损伤所致,临床表现类型与病理改变的程度关系密切。
In this paper, immunofluorescence and PAP method for 11 cases of autopsy Japanese encephalitis JE virus localization of brain antigens, and histological changes were observed. The results showed that immunofluorescence and PAP were positive in cytoplasm of 9 neurons (2 in severe type and 7 in common type), of which 7 were more common than 2 in severe type. Further confirmed the hypothesis that JE virus exists in the cytoplasm of the brain neurons and that the pathological changes that cause the brain tissue are caused by immune damage. The type of clinical manifestations is closely related to the degree of pathological changes.