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目的评估米诺环素与苄星青霉素治疗早期梅毒的血清学疗效。方法采用病例对照研究,将106例早期梅毒患者分为治疗组和对照组。治疗组42例患者予口服米诺环素100mg,2次/d,疗程15d;对照组64例患者予苄星青霉素240万U分两侧臀部肌肉注射,每周1次,共3周。结果米诺环素组患者的血清学治愈率为95.24%(40/42),苄星青霉素组患者为96.88%(62/64),两组治愈率差异无统计学意义(P>0.05),治疗组和对照组分别有2例治疗失败。米诺环素组患者皮损的消退时间稍晚于苄星青霉素组,但差异无统计学意义(P>0.05)。两组患者血清固定发生率分别为19.05%(8/42)和20.31%(13/64),差异无统计学意义(P>0.05)。结论米诺环素治疗早期梅毒效果显著,是苄星青霉素治疗梅毒可靠的替代药物。
Objective To evaluate the serological efficacy of minocycline and benzathine penicillin in the treatment of early syphilis. Methods A case-control study was conducted in which 106 patients with early syphilis were divided into treatment group and control group. In the treatment group, 42 patients were given oral minocycline 100 mg twice daily for 15 days. In the control group, 64 patients were given intramuscular injection of 2,4-benzathine penicillin on both buttocks once a week for 3 weeks. Results Serum cure rate was 95.24% (40/42) in patients receiving minocycline and 96.88% (62/64) in patients receiving benzathine penicillin. There was no significant difference in the cure rates between the two groups (P> 0.05) Treatment and control groups, respectively, two cases failed treatment. Minocycline patients with skin lesions subsided slightly later than the penicillin group, but the difference was not statistically significant (P> 0.05). Serum fixation rates in both groups were 19.05% (8/42) and 20.31% (13/64), respectively, with no significant difference (P> 0.05). Conclusion Minocycline is effective in treating early syphilis and is a reliable substitute for penicillin for the treatment of syphilis.