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目的探讨桃红四物汤联合米非司酮治疗子宫内膜异位症对患者相关炎性因子与激素水平的影响。方法选择2013年9月-2015年3月在该院接受治疗的144例子宫内膜异位症患者为研究对象,随机分为对照组72例与研究组72例。对照组采用米非司酮治疗,研究组在对照组基础上采用桃红四物汤治疗。比较治疗前、后两组患者相关炎性因子[白细介素-6(IL-6)、可溶性细胞间粘连因子-1(sI CAM-1)、基质金属蛋白酶-9(MMP-9)、血管内皮形成因子(VEGF)]、激素水平[(卵泡刺激素(FSH)、癌胚抗原125(CA125)、血清雌二醇(E_2)、孕酮(P)]、生存质量评分及不良反应发生率,并对两组临床疗效进行评价。结果与治疗前相比,两组IL-6、sI CAM-1、MMP-9、FSH、CA125、E_2水平经治疗均明显降低,而P水平明显升高,且研究组上述观察指标较对照组明显更好,差异具有统计学意义(P<0.05);治疗后,研究组与对照组生存质量评分分别为(82.68±1.69)分、(74.85±1.77)分,与治疗前(65.12±1.65)分、(65.36±1.74)分相比均明显升高,且研究组较对照组明显更高,差异具有统计学意义(P<0.05);研究组总有效率为94.44%(68/72),明显高于对照组76.39%(55/72),差异具有统计学意义(P<0.05);研究组总不良反应发生率为5.56%(4/72)与对照组4.17%(3/72)相比,差异无统计学意义(P>0.05)。结论采用桃红四物汤联合米非司酮治疗子宫内膜异位症,可显著提高临床疗效,且不良反应少,提高患者生存质量,对相关炎性因子与激素水平具有一定影响。
Objective To investigate the effects of Taohong Siwu Decoction combined with mifepristone on endometriosis in patients with inflammatory cytokines and hormone levels. Methods Seventy-four patients with endometriosis treated in our hospital from September 2013 to March 2015 were selected as study subjects and randomly divided into control group (72 cases) and study group (72 cases). The control group was treated with mifepristone, and the study group was treated with Taohong Siwu Tang on the basis of the control group. The levels of interleukin 6 (IL-6), sI CAM-1, MMP-9, MMP-9, (VEGF), hormone levels (FSH, CA125, E2 and progesterone), quality of life scores and adverse reactions And the clinical efficacy of the two groups were evaluated.Results The levels of IL-6, sI CAM-1, MMP-9, FSH, CA125 and E_2 in both groups were significantly decreased after treatment, while the levels of P were significantly increased (P <0.05). After treatment, the quality of life scores of the study group and the control group were (82.68 ± 1.69), (74.85 ± 1.77, P <0.05), and the above indexes in the study group were significantly better than those in the control group ) Was significantly higher than that before treatment (65.12 ± 1.65), (65.36 ± 1.74) points, and the study group was significantly higher than the control group, the difference was statistically significant (P <0.05); study group total The effective rate was 94.44% (68/72), which was significantly higher than 76.39% (55/72) in the control group, the difference was statistically significant (P <0.05). The total adverse reaction rate in the study group was 5.56% (4/72) And control group 4.17% (3/72 (P0.05) .Conclusion The treatment of endometriosis with Taohong Siwu Decoction combined with mifepristone can significantly improve the clinical curative effect with less adverse reactions, improve the quality of life of patients, On the relevant inflammatory factors and hormone levels have a certain impact.