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笔者已发现肿瘤组织比正常组织能产生较多的前列腺素(PGs),并且用大鼠的胃底生物测定法分别测定了从乳癌组织匀浆中和乳房良性肿瘤及正常乳房组织中提取的前列腺素样物质(PG-LM,以 PGE_2形式为主),发现乳癌患者高于后二者。这表明 PGs 可能与乳癌有一定的关系。为了研究 PGs 对乳癌可能产生的作用,笔者测定了141例乳癌组织中提取的 PG-LM 的量,并研究了 PG-LM 与已知的影响预后因素的关系。这些因素是病人的年龄、绝经情况、肿瘤大小、组织分型、恶性度、纤维组织的数量、癌向骨骼、血管及淋巴组织转移的情况以
The authors have found that tumor tissues produce more prostaglandins (PGs) than normal tissues, and the prostate biopsies were used to determine prostates extracted from breast cancer tissue homogenates, benign breast tumors, and normal breast tissue. The prime substance (PG-LM, predominantly in the PGE 2 form) was found to be higher in breast cancer patients than in the latter two. This shows that PGs may have a certain relationship with breast cancer. To investigate the possible role of PGs in breast cancer, the authors measured the amount of PG-LM extracted from 141 breast cancer tissues and studied the relationship between PG-LM and known prognostic factors. These factors are the patient’s age, menopausal status, tumor size, histological type, malignancy, number of fibrous tissue, cancer to bone, and vascular and lymphoid tissue metastases.