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采用 5/ 6肾切除方法复制大鼠CRF动物模型 ,并随机分成滋肾活血解毒方、洛汀新、保肾康、病理对照及正常对照组 ,用放射免疫分析法检测血中IL 8、TNFα及SOD水平。结果示各CRF模型组大鼠血中IL 8、TNFα水平高于正常对照组 ,血中SOD水平低于正常对照组 ;滋肾活血解毒方、洛汀新组大鼠血中Cr、BUN水平低于保肾康及病理对照组 ;滋肾活血解毒方组大鼠血中IL 8、TNFα水平明显低于洛汀新、保肾康及病理对照组 ,而血中SOD水平明显高于 3组对照。结果表明滋肾活血解毒方有明显改善肾功能的作用 ,其机理与降低或阻断IL 8、TNFα分泌 ,抗细胞组织过氧化 ,减轻肾小球硬化有关。
The rat model of CRF was replicated by 5/6 nephrectomy and randomly divided into Zishen Huoxue Jiedu Fang, Luo Tingxin, Baoshenkang, pathological control and normal control group. IL 8 and TNFα in blood were detected by radioimmunoassay. And SOD levels. The results showed that the serum levels of IL-8 and TNFα in the CRF model group were higher than those in the normal control group. The SOD level in the blood was lower than that in the normal control group; the levels of Cr and BUN in the blood of the Zishen Huoxue Jiedu Fang and Luotingxin group were low The serum levels of IL-8 and TNFα in the rats of Zishen Huoxue Jiedu Decoction group were significantly lower than those of Lotensin, Baoshenkang, and the pathological control group, and the level of SOD in the blood was significantly higher than that of the three groups. . The results showed that Zishen Huoxue Jiedu Decoction can significantly improve renal function, and its mechanism is related to reducing or blocking the secretion of IL-8, TNFα, anti-cell tissue peroxidation, and reducing glomerular sclerosis.