关于单纯性粘膜白斑的病因,迄今只探寻到一些有关的因素。但不能确定何种因素在发病中起着独特的、决定性的作用。从六十年代开始,Cawson 等开始注意到口腔粘膜白斑与慢性白色念珠菌感染的密切关系。Cawson 和 Lehner 报告:口腔粘膜粒状白斑中遭受白色念珠菌感染者占61%,An-dreasen 在白斑病变的组织学检查时发现有10%的病例由白色念珠菌病(Candidiasis)转化而来。Pindborg 也曾报告48例斑纹状白斑伴有白色念珠菌感染。Cawsian 等在电镜下 About the cause of simple leukoplakia, so far only to find some relevant factors. But can not determine what kind of factors play a unique and decisive role in the pathogenesis. Since the 1960s, Cawson et al. Began to notice the close relationship between oral leukoplakia and chronic Candida albicans infection. Cawson and Lehner report that 61% of those with Candida albicans were infected with oral leukoplakia, and An-dreasen was found to have transformed 10% of Candida albicans cases by histological examination of white spot lesions. Pindborg also reported 48 cases of leukoplakia accompanied by Candida albicans infection. Cawsian et al. Under electron microscopy