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目的:观察酮咯酸氨丁三醇预防小儿扁桃体摘除术全麻苏醒期躁动的效果。方法:选择小儿扁桃体摘除术患者48例,随机分为治疗组和对照组各24例。治疗组患儿于手术结束前15 min给予静脉注射酮咯酸氨丁三醇注射液0.5 mg/kg,对照组患儿静脉注射等量0.9%NaCl。结果:治疗组与对照组的平均躁动评分,术毕5 min(T1)分别为(1.35±0.68)分和(2.08±0.72)分,拔管时(T2)分别为(1.80±0.73)分和(2.31±0.60)分,拔管后10 min(T3)分别为(0.96±0.45)分和(1.32±0.49)分,拔管后20 min(T4)分别为(0.73±0.42)分和(1.03±0.65)分,治疗组患儿躁动的发生率比对照组低,两组比较差异均有统计学意义(P<0.05);两组患儿的呼吸频率恢复正常时间、睁眼时间、拔管时间比较差异无统计学意义(P>0.05)。结论:手术结束前15 min给予静脉注射酮咯酸氨丁三醇注射液0.5 mg/kg,可减少小儿扁桃体摘除术全麻苏醒期躁动的发生,且无明显不良反应。
OBJECTIVE: To observe the effect of ketorolac tromethamine on restlessness of general anesthesia in pediatric tonsillectomy. Methods: Forty-eight patients with pediatric tonsillectomy were randomly divided into treatment group (24 cases) and control group (24 cases). The patients in the treatment group were given intravenous injection of ketorolac tromethamine 0.5 mg / kg 15 min before the end of surgery, and the control group received 0.9% NaCl intravenously. Results: The average agitation scores of the treatment group and the control group were (1.35 ± 0.68) points and (2.08 ± 0.72) points respectively at 5 min after operation and (1.80 ± 0.73) points at the time of extubation (2.31 ± 0.60) points and (0.96 ± 0.45) points and (1.32 ± 0.49) points respectively at 10 min after extubation and (0.73 ± 0.42) and ± 0.65) points, the incidence of agitation in treatment group was lower than that in control group, and there was significant difference between the two groups (P <0.05); the respiration rate of normal children in two groups recovered to normal time, There was no significant difference in time (P> 0.05). CONCLUSION: Intravenous injection of ketorolac tromethamine 0.5 mg / kg 15 min before the end of surgery reduces the onset of agitation during general anesthesia in children with tonsillectomy and has no apparent adverse reactions.