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目的 :评估α1 微球蛋白 (α1 MG)在妊高征早期肾损害诊断中的意义。方法 :测定 44例妊高征患者血、尿α1 MG的含量。结果 :轻、中、重各组妊高征患者血α1 MG水平显著高于正常孕妇组 ,而 β2 MG、Scr、BUN在轻度妊高征尚未升高。各组妊高征患者血α1 MG水平升高的阳性率均显著高于血 β2 MG水平升高的阳性率。在轻、中、重度妊高征组 ,尿α1 MG及其排泄分数显著升高 ,而在轻度妊高征组中尿 β2 MG及其排泄分数尚未升高。结论 :血、尿α1 MG可作为反映妊高征患者肾小球、肾小管功能受损的早期指标 ,敏感性高于血、尿 β2 MG、Scr及BUN。
PURPOSE: To evaluate the significance of α1 microglobulin (α1 MG) in the diagnosis of early renal damage induced by pregnancy-induced hypertension. Methods: The blood and urinary α1 MG levels were measured in 44 patients with PIH. Results: The blood levels of α1 MG in patients with PIH were significantly higher than those in normal pregnant women, while β2 MG, Scr and BUN were not elevated in mild PIH. The positive rates of elevated blood α1 MG levels in patients with PIH were significantly higher than those of elevated blood β2 MG levels in each group. In light, moderate and severe pregnancy induced hypertension group, urinary α1 MG and its excretion fraction increased significantly, while in the mild PIH group urinary β2 MG and its excretion fraction had not increased. CONCLUSION: Blood and urine α1 MG can be used as early indicators of impaired glomerular and renal tubular function in patients with PIH, and their sensitivity is higher than that of blood and urine β2 MG, Scr and BUN.