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[目的]观察益气解毒软肝汤联合西药治疗乙型肝炎后肝硬化疗效。[方法]使用随机平行对照方法,将60例住院患者按抽签法随机分为两组。对照组30例常规治疗,抗病毒(拉米夫定、阿德福韦酯或恩替卡韦等)、保肝、降酶退黄,合并腹水口服利尿剂,严格限制钠盐摄入。治疗组30例益气解毒软肝汤(黄芪、炒白术各20g,黄精30g,首乌15g,百花虫舌草30g,丹参15g,柴胡10g,虎杖、半枝莲、茯苓、枸杞子各15g,山茱萸10g,赤芍15g),1剂/d,水煎400mL,早晚口服;西药治疗同对照组。连续治疗90d为1疗程。观测临床症状、TBIL、ALT、ALB、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效7例,有效18例,无效5例,总有效率83.33%。对照组显效1例,有效17例,无效12例,总有效率60.00%。治疗组疗效优于对照组(P<0.05)。肝功能指标两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]益气解毒软肝汤联合西药治疗乙型肝炎后肝硬化效果显著,值得推广。
[Objective] To observe the curative effect of Yiqi Jiedu RuanGan Decoction combined with western medicine on post-hepatitis B cirrhosis. [Methods] Randomized parallel method was used to divide 60 hospitalized patients into two groups according to random selection. Control group, 30 cases of conventional treatment, antiviral (lamivudine, adefovir dipivoxil or entecavir, etc.), liver protection, reducing enzyme yellow, combined with ascites oral diuretics, strict restrictions on sodium intake. Treatment group of 30 cases of Qi and Liver detoxification soup (Astragalus, Atractylodes each 20g, Polygonatum 30g, Radix 15g, Radix Scutellariae 30g, Salvia 15g, Bupleurum 10g, Polygonum, Scutellaria barbata, Poria, medlar 15g , Dogwood 10g, red peony root 15g), 1 / d, decoction 400mL, sooner or later oral; western medicine treatment with the control group. Continuous treatment of 90d for a course of treatment. Observed clinical symptoms, TBIL, ALT, ALB, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. [Results] The treatment group markedly effective in 7 cases, 18 cases effective, 5 cases ineffective, the total effective rate was 83.33%. The control group was markedly effective in 1 case, effective in 17 cases, ineffective in 12 cases, the total effective rate was 60.00%. The treatment group was better than the control group (P <0.05). Liver function indicators improved in both groups (P <0.05), the treatment group improved better than the control group (P <0.05). [Conclusion] Yiqi Jiedu RuanGan Decoction combined with Western medicine has significant effect on cirrhosis after hepatitis B, which is worth to be popularized.