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为有效地预防肾综合征出血热（ＨＦＲＳ）的发生与流行，对沙鼠肾细胞型灭活疫苗的安全性及血清学、流行病学效果进行观察。结果：疫苗接种总反应率０．８９％（５５７／６２３１１），中反应率０．０３％（１９／６２３１１）；疫苗基础免疫全程接种两周后的血清中和抗体阳转率７０．３７％（３８／５４），荧光抗体阳转率８３．３３％（２５／３０）；垦区ＨＦＲＳ冬季主要宿主动物为黑线姬鼠，占６２．６１％（３６０／５７５），野外黑线姬鼠密度１１．１３％（２０４／１８３３），带病毒率６．０４９６（９／１４９），带病毒鼠指数０．０８２０；ＨＦＲＳ病人血清ＩｇＧ抗体检测为Ⅰ型，流行峰型为冬峰型，秋冬季节（８～１月份）发病人数占９３．９１％；健康人群隐性感染率３．４７％（５６／１６１６）。１９９５年１０～１２月份，疫苗全程接种组人群ＨＦＲＳ发病率０（０／１７１２７），全程非接种组人群发病率１０１．３６／１０万（１４４／１４２０６１），保护率１００％。由此显示：黑龙江垦区ＨＦＲＳ疫区类型为姬鼠型；该疫苗具有较高的安全性和较好的近期防病效果。
In order to effectively prevent the occurrence and prevalence of hemorrhagic fever with renal syndrome (HFRS), the safety, serological and epidemiological effects of gerbil-derived renal cell vaccine were observed. Results: The total response rate of vaccination was 0.89% (557/62311), and the medium response rate was 0.03% (19/62311). The positive rate of serum neutralizing antibody in the two weeks after vaccination was 70.37% (38/54), and the positive rate of fluorescent antibody was 83.33% (25/30). The main host animals of HFRS in reclamation area in winter were Apodemus agrarius, accounting for 62.61% (360/575), the density of Apodemus agrarius 11.13% (204/1833), with a virus rate of 6.0496 (9/149) and a viral mouse index of 0.0820. The serum IgG antibody of type I HFRS was detected as type I and the epidemic peak type was winter peak, (August to January) accounted for 93.91% of the number of patients; the prevalence of latent infection in healthy population was 3.47% (56/1616). From October to December 1995, the incidence of HFRS in vaccinated group was 0 (0/17127), and the incidence of HFRS in non-vaccinated group was 101.36 / 100000 (144/142061). The protection rate was 100%. It shows that the type of HFRS in Heilongjiang Reclamation Area is Apodemus type; the vaccine has high safety and good effect in preventing disease in the near future.