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目的比较液基细胞学检查和DNA定量分析法在女性宫颈病变中的应用及其临床意义。方法对参与对比的879例妇女用宫颈刷取材,进行液基薄层制片,分别进行巴氏染色和DNA染色。对巴氏染色片做液基细胞学检查,并对DNA染色片进行全自动扫描诊断。结果对液基细胞学检查结果显示病变程度在非典型鳞状上皮细胞(ASCUS)意义不明以上病例和全自动DNA倍体分析系统检测见异倍体细胞部分病例,建议进一步做阴道镜检查及宫颈活检。28例妇女做了病理活检。以细胞诊断结果为标准,计算出细胞DNA定量分析法在ASCUS以上宫颈病变的检出率。结论细胞DNA定量分析法与液基细胞学检查组合应用,能明显提高宫颈癌及癌前病变的阳性检出率,对我国女性宫颈癌的防治具有重要的意义。
Objective To compare the application of liquid-based cytology and DNA quantitative analysis in female patients with cervical lesions and its clinical significance. Methods A total of 879 women participating in the study were treated by cervical brushing and liquid-based thin-layer filming, respectively, for Pap smear and DNA staining. Pap smear liquid-based cytology, and DNA staining for automatic scanning diagnosis. Results of liquid-based cytology examination showed that the degree of lesion in the atypical squamous epithelial cells (ASCUS) unknown meaning above cases and automatic DNA ploidy analysis system detected aneuploid cells in some cases, it is recommended to do further colposcopy and cervical Biopsy. Twenty-eight women underwent biopsy. Based on the results of cytodiagnosis, the detection rate of cervical lesions above ASCUS by DNA quantitative analysis was calculated. Conclusion The combined application of DNA quantitative analysis and liquid-based cytology can significantly improve the positive detection rate of cervical cancer and precancerous lesions and is of great significance for the prevention and treatment of cervical cancer in our country.