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[目的] 研究健胃愈疡颗粒对胃溃疡的治疗作用及作用机制。[方法] 以 Okabe改良法复制大鼠实验性胃溃疡模型,设正常组、假手术组、模型组、雷尼替丁组、健胃愈疡组,检测溃汤指数和胃黏膜中一氧化氮(NO)水平。[结果] 健胃愈疡颗粒能显著降低溃疡指数(灌药 7 d为 1 67±0 49,与其他组比较, P<0 05;灌药 14 d为0 80±0 42,与其他组比较,P<0 01),显著提高胃黏膜NO水平[灌药14 d后为(0 597±0 042)μmol/g蛋白,与其他组比较,P<0 01]。[结论] 健胃愈疡颗粒可能通过诱导和促进胃黏膜NO的生成促进溃疡愈合。
[Objective] To study the therapeutic effect and mechanism of Jianweiyuyang granule on gastric ulcer. [Methods] Rat experimental gastric ulcer model was modified by Okabe’s modified method. The normal group, sham operation group, model group, ranitidine group and Jianweiyuyang group were set up to detect ulceration index and nitric oxide in gastric mucosa. (NO) level. [Results] Jianweiyuyang granules can significantly reduce the ulcer index (during 7 d of irrigation, 167 ± 0 49, compared with other groups, P <0 05; 14 d of irrigation, 0 80 ± 0 42, compared with other groups. ,P<0 01),significantly increased the level of NO in gastric mucosa [(0 597±0 042)μmol/g protein after 14 d of infusion, compared with other groups, P<0 01]. [Conclusion] Jianwei Yuyang Granules may promote ulcer healing by inducing and promoting NO production in gastric mucosa.