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目的 探讨表达CD 7抗原的急性髓性白血病 (AML)患儿的临床特点及治疗反应。方法 选择上海儿童医学中心和广州医学院第二附属医院住院治疗的AML患儿 2 8例。应用一组CD系列单克隆抗体随机检测其表型 ,用G显带进行染色体核型分析。治疗采用上海儿童医学中心常规化疗方案。将CD7+ 与CD7-的AML进行对比。结果 CD7+ 与CD7-AML相比 ,具有肝大、外周血白细胞数高 ,原始细胞百分比高、第一疗程达CR者少、P170率高的特点 (均为P <0 0 5 )。结论 CD7+ AML临床症状较重 ,治疗反应较差 ,预后欠佳。
Objective To investigate the clinical features and therapeutic response of children with acute myelogenous leukemia (AML) expressing CD7 antigen. Methods Twenty-eight AML children hospitalized in Shanghai Children’s Medical Center and the Second Affiliated Hospital of Guangzhou Medical College were selected. A panel of CD-series monoclonal antibodies was used to detect its phenotype at random, followed by G-banding for karyotype analysis. Treatment Shanghai Children’s Medical Center conventional chemotherapy. The CD7 + and CD7- AML were compared. Results Compared with CD7-AML, CD7 + had the features of large liver and peripheral blood leukocytes, high percentage of blasts, less CR in the first course of treatment and higher P170 rate (all P <0.05). Conclusion The clinical symptoms of CD7 + AML are severe, the treatment response is poor, and the prognosis is poor.