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目的:探讨胰腺残端捆绑结扎对胰腺远端切除术后胰瘘的影响。方法:采用回顾性病例对照研究方法。收集2011年1月至2018年8月内蒙古医科大学附属医院收治的60例胰体尾部病变行胰腺远端切除术病人的临床资料；男24例，女36例；中位年龄为45岁，年龄范围为19~68岁。60例病人中，36例离断胰腺仅采用直线切割闭合器，设为未捆绑组；24例离断胰腺前在距离胰腺离断处近端>1 cm用10号或7号丝线予以捆绑结扎，设为捆绑组。观察指标：（1）术后恢复情况。（2）影响胰腺远端切除术后胰瘘的危险因素分析。正态分布的计量资料以n x±s表示，组间比较采用n t检验或ANOVA检验；偏态分布的计量资料以n M（范围）表示。计数资料以绝对数表示，组间比较采用n χ2检验。单因素分析采用n χ2检验，多因素分析采用Logistic回归模型。n 结果:（1）术后恢复情况：未捆绑组病人术后淀粉酶、生化漏、B级胰瘘、并发症、拔除引流管时间、术后住院时间、总住院费用分别为（2 629±592）U/L、14例、5例、7例、（11.9±0.7）d、（13.6±0.7）d、（49 430±1 626）元，捆绑组病人上述指标分别为（683±312）U/L、3例、1例、2例、（9.7±0.6）d、（11.3±0.5）d、（44 767±1 163）元，两组病人术后淀粉酶、生化漏、拔除引流管时间、术后住院时间、总住院费用比较，差异均有统计学意义（n t=2.528，n χ2=1.512，n t=2.341、2.311、2.111，n P0.05）。（2）影响胰腺远端切除术后胰瘘的危险因素分析：单因素分析结果显示肿瘤长径和胰腺残端捆绑结扎是影响胰腺远端切除术后胰瘘的相关因素（n χ2=4.462，5.061，n P<0.05）。多因素分析结果显示胰腺残端捆绑结扎是胰腺远端切除术后胰瘘的独立影响因素（优势比=0.187，95%可信区间为0.037~0.954，n P<0.05）。n 结论:胰腺残端捆绑结扎是胰腺远端切除术后胰瘘的独立影响因素，该方式可有效降低胰腺远端切除术后胰瘘特别是生化漏发生率，缩短引流管留置时间和术后住院时间，促进病人恢复并降低总住院费用。“,”Objective:To investigate the influence of bundled ligation of the pancreatic stump on postoperative pancreatic fistula (POPF) of distal pancreatectomy (DP).Methods:The retrospective case-control study was conducted. The clinical data of 60 patients with diseases in pancreatic body and tail who underwent DP in the Affiliated Hospital of Inner Mongolia Medical University from January 2011 to August 2018 were collected. There were 24 males and 36 females, aged from 19 to 68 years, with a median age of 45 years. Of the 60 patients, 36 cases undergoing dissection of pancreas with Endo-GIA stapler were allocated into non-bundled group, and 24 cases undergoing bundled ligation of the pancreatic stump with No.10 or No.7 suture at the site over 1 cm of the resection site before dissection of pancreas were allocated into bundled group. Observation indicators: (1) postoperative situations; (2) analysis of risk factors for POPF of DP. Measurement data with normal distribution were represented as n Mean±n SD, and comparison between groups was analyzed using the n t test or ANOVA test. Measurement data with skewed distribution were represented as n M (range).Count data were described as absolute numbers, and comparison between groups was analyzed using the chi-square test. Univariate analysis was conducted using the chi-square test and multivariate analysis was conducted using the Logistic regression model.n Results:(1) Postoperative situations: the amylase concentration, cases with biochemical fistula, cases with grade B pancreatic fistula, cases with complications, time to extubation, duration of postoperative hospital stay, total hospital expenses were (2 629±592)U/L, 14, 5, 7, (11.9±0.7)days, (13.6±0.7)days, (49 430±1 626)yuan in non-bundled group and (683±312)U/L, 3, 1, 2, (9.7±0.6)days, (11.3±0.5)days, (44 767±1 163)yuan in bundled group, respectively. There were significant differences in the amylase concentration, cases with biochemical fistula, time to extubation, duration of hospital stay, total hospital expenses between the two groups (n t=2.528, n χ2=1.512, n t=2.341, 2.311, 2.111, n P0.05). (2) Analysis of risk factors for POPF of DP. Results of univariate analysis showed that tumor diameter and bundled ligation of the pancreatic stump were related factors of patients undergoing pancreatic fistula after DP (n χ2=4.462, 5.061, n P<0.05). Results of multivariate analysis showed that bundled ligation of the pancreatic stump was an independent influencing factor of patients undergoing pancreatic fistula after DP (n odds ratio=0.187, 95% n confidence interval as 0.037-0.954, n P<0.05).n Conclusions:Bundled ligation of the pancreatic stump was an independent influencing factor of patients undergoing pancreatic fistula after DP. Bundled ligation of the pancreatic stump can effectively reduce the incidence of POPF, especially biochemical fistula, the time to extubation, duration of postoperative hospital stay and total hospital expenses, and promote patient recovery after DP.