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目的:观察卵胞浆内单精子注射(ICSI)使用经皮睾丸穿刺取精(PTSA)、PTSA后冷冻精子及体外射出精子的临床结局。方法:对2009年2-12月接受ICSI治疗的168个周期进行回顾性分析。168个周期分为3组,体外射精组95个周期,PTSA组41个周期,PTSA后冷冻精子组32个周期。对这3组的受精、胚胎、妊娠情况进行比较。结果:PTSA组、PTSA后冷冻精子组与体外射精组比较,每个周期受精卵数、卵裂数、移植胚胎数、优质胚胎数、临床妊娠率、自然流产率、分娩率等无统计学差异。结论:对于无精症患者,PTSA结合ICSI是一种有效的治疗手段,PTSA后冷冻精子对临床结局没有影响。
Objective: To observe the clinical outcomes of intracytoplasmic sperm injection (ICSI) using percutaneous testicular biopsy (PTSA), frozen sperm after PTSA and in vitro sperm injection. Methods: A retrospective analysis was performed on 168 cycles of ICSI treatment from January to December in 2009. 168 cycles were divided into 3 groups, 95 cycles of in vitro ejaculation group, 41 cycles of PTSA group and 32 cycles of frozen sperm group after PTSA. The three groups of fertilization, embryo and pregnancy were compared. Results: Compared with in vitro ejaculation group, PTSA group, post-PTSA frozen sperm group had no significant difference in number of fertilized eggs, number of cleavage, number of embryos transferred, number of high quality embryos, clinical pregnancy rate, spontaneous abortion rate and delivery rate . CONCLUSIONS: PTSA combined with ICSI is an effective treatment for patients with azoospermia, and frozen sperm after PTSA have no effect on clinical outcomes.