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本文对乙型肝炎患者(简称乙肝)有、无乙肝病毒复制者的细胞免疫功能状态进行了检测，以HBeAg、HBVDNA-PCR的均阳性为复制指标，HBeAg、HBeAg HBVDNA-PCR均阳性为非复制指标，52例患者，复制及非复制组各26例。结果为：乙肝病毒（HBV）复制组CD_4~+/CD_3~+为1.36±0.34,非复制组2.99±0.061,P＜0.05;NK细胞活性测定复制组为40.01±12.48,非复制组68.80±9.82,P＜0.01; LAK细胞活性测定，复制组为44.20±11.51,非复制组为67.90±9.82,P＜0.01结果表明，有病毒复制者的细胞免疫功能明显低下，说明细胞免疫功能状况对HBV复制具有明显影响，此为乙肝具有病毒复制者，治疗上使用免疫促进剂提供了依据。
In this paper, we examined the cellular immune status of hepatitis B patients with or without hepatitis B virus (HBV) replication. Both HBeAg and HBVDNA-PCR were positive for replication, HBeAg and HBeAg HBVDNA-PCR were positive for non-replication Indicators, 52 patients, 26 cases of replication and non-replication group. The results were as follows: the CD_4 ~ + / CD_3 ~ + of HBV replication group was 1.36 ± 0.34, the non-replication group was 2.99 ± 0.061, P <0.05; the activity of NK cells replication group was 40.01 ± 12.48 and the non-replication group was 68.80 ± 9.82 , P <0.01. The activity of LAK cells was 44.20 ± 11.51 in the replication group and 67.90 ± 9.82 in the non-replication group, P <0.01. The results showed that the cellular immune function of virus replication was obviously low, Has a significant impact, this is hepatitis B virus replication, the use of immunosuppressive agents provide the basis.