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AU-rich element(AU富集元件,ARE)是在快速反应性基因中广泛存在的一类转录后调控元件,对mRNA的稳定及其翻译效率起到重要的调控作用。miRNA是一类长度为19～23 bp的小RNA,研究发现其在生命活动的各个环节都发挥着重要的转录后调控作用,通过种子序列的识别作用介导靶mRNA的降解或翻译的抑制。美国哈佛医学研究所分子生物物理与生物化学研究小组在研究ARE的调控作用中发现了miRNA有活化翻译的作用。
AU-rich elements (AREs) are a type of post-transcriptional regulatory element that exists widely in rapidly reactive genes and plays an important regulatory role in the stability of mRNA and the translation efficiency. MiRNAs are small RNAs of 19-23 bp in length and have been found to play an important post-transcriptional regulatory role in all aspects of life activity. miRNAs mediate the degradation of target mRNAs or the inhibition of translation through the recognition of seed sequences. Harvard Medical Research Institute of Molecular Biophysics and Biochemistry team in the study of the regulatory role of ARE found miRNAs have the role of activation of translation.