目的　探讨血液灌流抢救急性毒物中毒患者血小板变化及其临床意义。方法　检测 2 4例急性毒物中毒患者炭肾血液灌流前 30分钟及治疗后 12小时血小板数量。结果　患者血液灌流前血小板为(137.38± 36 .82 )× 10 9/L ,血液灌流后为 (85 .5 0± 2 0 .89)× 10 9/L ,比治疗前明显降低 (P <0 .0 1) ,红细胞及白细胞无明显变化。结论　应用炭肾血液灌流抢救急性毒物中毒可能引起血小板明显降低 ,应进行全程监测 ,预防出血 ,提高中毒患者的抢救成功率。 Objective To investigate the changes of platelet in hemoperfusion patients after acute poisoning and its clinical significance. Methods Twenty-four hours before carbon monoxide hemoperfusion in 24 acute poisoning patients, the number of platelets was measured. Results The level of platelet before hemoperfusion was (137.38 ± 36.82) × 10 9 / L and (85.5 ± 20.89) × 10 9 / L after hemoperfusion, which was significantly lower than that before treatment (P <0 .0 1), no significant changes in red blood cells and white blood cells. Conclusion The application of charcoal hemoperfusion to rescue acute toxic poisoning may cause a significant decrease of platelets, and should be monitored in the whole process to prevent hemorrhage and improve the success rate of rescue in patients with poisoning.