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目的:分析天水市新生儿先天性甲状腺功能减低症(CH)的筛查和发病情况。方法:新生儿出生72 h后采集足跟血3滴渗于滤纸片上,应用时间分辨荧光免疫分析法检测干血片中促甲状腺激素(TSH)水平。TSH≥8μIU/ml的新生儿视为可疑阳性,召回复查并进一步确诊。结果:筛查覆盖率从2009年的22.04%提高到2013年的97.35%。5年筛查145 233例新生儿。确诊CH患儿67例,发病率为4.61/万,农村地区发病率明显高于城区(P<0.05)。结论:天水市新生儿CH发病率高于全国平均水平,且有区域高发的特征。通过筛查和及早诊断治疗,使患儿体格发育和智力发育达到正常水平,减少弱智儿童的发病率,为提高人口素质奠定了基础。
Objective: To analyze the screening and incidence of neonatal congenital hypothyroidism (CH) in Tianshui City. Methods: Three hours after the birth of a newborn baby, heel blood was collected and infiltrated on filter paper. The level of thyroid stimulating hormone (TSH) in dried slices was detected by time-resolved fluorescence immunoassay. Newborns with TSH ≥8μIU / ml were considered suspicious and were recalled and further diagnosed. Results: Screening coverage increased from 22.04% in 2009 to 97.35% in 2013. Five-year screening 145 233 newborns. The diagnosis of CH in 67 cases, the incidence was 4.61 / million, the incidence of rural areas was significantly higher than the city (P <0.05). Conclusion: The incidence of neonatal CH in Tianshui City is higher than the national average and has the characteristics of high incidence in the region. Through screening and early diagnosis and treatment, so that physical development and mental development in children with normal levels, reduce the incidence of mentally retarded children, in order to improve the quality of population laid the foundation.