目的:探讨早期诊断、积极治疗、动态观察妊娠期肝内胆汁淤积症(ICP)对母儿预后的影响。方法:对3年中来我院治疗及分娩的56例ICP患者资料进行回顾性分析,按照就诊情况分为治疗组及未治疗组,治疗组:给予地塞米松、熊去氧胆酸(UDCA)联合中药茵陈汤交替治疗,孕期一直坚持治疗、动态观察ALT、AST、TBA生化指标变化,并B超监护、严密观察NST反应;未治疗组:孕期未及时就诊,至临产入院才发现或虽经治疗但中途不能坚持者。结果:治疗组围产儿死亡率、羊水粪染、新生儿窒息、早产发生率明显低于未治疗组。结论:地塞米松、UDCA、中药茵陈汤是治疗ICP安全有效的药物,三种药物联合交替、间歇使用,则是治疗ICP比较简便、合理、有效的方法,而对ICP早期诊断、及时治疗、严密观察、积极干预、适时终止妊娠是改善妊娠结局的关键。 Objective: To explore the early diagnosis, active treatment, dynamic observation of intrahepatic cholestasis of pregnancy (ICP) on the prognosis of maternal and child. Methods: The data of 56 patients with ICP who were treated and delivered in our hospital during 3 years were retrospectively analyzed. According to the treatment, the patients were divided into treatment group and untreated group. The treatment group was given dexamethasone, ursodeoxycholic acid (UDCA) ) Combined with traditional Chinese medicine Yin Chen Tang alternating treatment, has been insisting on treatment during pregnancy, dynamic observation ALT, AST, TBA changes in biochemical indicators, and B super-monitoring, close observation of NST response; untreated group: pregnancy did not timely treatment, Although treated but can not adhere to half-way. Results: The perinatal mortality, meconium-stained amniotic fluid, neonatal asphyxia and preterm delivery in the treatment group were significantly lower than those in the untreated group. Conclusions: Dexamethasone, UDCA and Chinese herb Yinchen Tang are safe and effective drugs for the treatment of ICP. The three drugs combined with alternating and intermittent use are the simple, reasonable and effective methods for the treatment of ICP. However, the early diagnosis and timely treatment of ICP , Close observation, positive intervention, timely termination of pregnancy is the key to improving pregnancy outcomes.