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目的探讨不同G值的间断性 -Gx暴露对抗模拟失重下大鼠脑基底动脉血管反应性改变的效果。方法用大鼠在 1 .5G或 2 .6G的离心机上离心模拟不同G值间断性 -Gx暴露 ,分别给予大鼠 (尾悬吊 3wk) 1h/d -Gx作用 ,测定大鼠离体基底动脉血管环对KCl的收缩反应性。结果悬吊组大鼠基底动脉血管环对KCl的最大反应较对照组显著升高 (P <0 .0 5) ;间断性 -Gx重力暴露组大鼠基底动脉血管环对KCl的最大反应较悬吊组显著减弱 (P <0 .0 5) ,与对照组无显著差别。结论间断性 -Gx暴露可对抗模拟失重对大鼠脑动脉血管反应性的影响 ,而这种对抗作用不随重力G值的改变而改变
Objective To investigate the effect of intermittent-Gx exposure with different G value on the changes of cerebral basilar artery vasoreactivity in rats under simulated weightlessness. Methods Rats were exposed to intermittent-Gx exposures at different G values by centrifugation on a 1.5G or 2.6G centrifuge, and the rats were given 1h / d-Gx at the end of 3wk respectively. The isolated basilar artery Vasoconstrictive effect of KCl on vasoconstriction. Results The maximal response of basilar artery rings in suspension group to KCl was significantly higher than that in control group (P <0.05). The maximal reaction of basilar artery rings in intermittent-Gx group was more pronounced than KCl in suspension group Hanging group significantly weakened (P <0. 05), with no significant difference between the control group. Conclusion Intermittent-Gx exposure can counteract the effects of simulated weightlessness on cerebral arterial reactivity in rats, and this antagonistic effect does not change with the change of G value