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为了控制氢溴酸右美沙芬质量,合成分离了欧洲药典7.4版收载的有关物质D:3-甲氧基-17-甲基-(9?,13?,14?)-吗啡喃;为便于质控称量和贮藏,制备了有关物质D的苦味酸盐,其结构经MS、1H NMR、13C NMR和X-射线单晶衍射确证。
In order to control the quality of dextromethorphan hydrobromide, the related substance D contained in the European Pharmacopoeia 7.4 edition was isolated and synthesized. The substance D (3-methoxy-17-methyl- (9 ?, 13 ?, 14?) - Which is convenient for quality control weighing and storage. Picrate of related substance D was prepared and its structure was confirmed by MS, 1H NMR, 13C NMR and X-ray single crystal diffraction.