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目的:探讨大肠癌组织中血管内皮生长因子-C(VEGF-C)的表达及其与临床病理指标和预后的关系. 方法:应用免疫组化SP法检测96例大肠癌组织中VEGF- C的表达,并分析其与大肠癌临床病理指标和预后的关系. 结果:大肠癌组织VEGF-C阳性率明显高于正常大肠组织(42/96 vs 19/96,P<0.01);大肠癌VEGF-C表达与大肠癌分化程度、Dukes分期、淋巴结转移及患者预后密切相关(P<0.01或P<0.05),但是与患者年龄、性别、肿瘤大小、部位、浸润深度以及远处器官转移无关(P>0.05).41 例有淋巴结转移病例的转移灶和原发灶癌组织的VEGF-C 表达相当一致(P<0.01). 结论:VEGF-C可能通过诱导淋巴管生成促进大肠癌淋巴结转移,并且可以作为指导大肠癌治疗和判断预后的一个重要指标.
Objective: To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and its relationship with clinicopathological parameters and prognosis in colorectal cancer.Methods: The expression of VEGF-C in 96 colorectal cancer tissues was detected by immunohistochemical SP method (P <0.01). The positive rates of VEGF-C in colorectal cancer tissues were significantly higher than those in normal colorectal tissues (42/96 vs 19/96, P <0.01) (P <0.01 or P <0.05), but not with the age, sex, tumor size, location, depth of invasion and distant organ metastasis (P <0.01 or P <0.05) > 0.05) .The expression of VEGF-C in 41 cases with lymph node metastasis and in primary cancerous tissues was consistent (P <0.01) .Conclusion: VEGF-C may promote lymph node metastasis of colorectal cancer by inducing lymphangiogenesis, and It can be used as a guide to guide the treatment of colorectal cancer and prognosis of an important indicator.