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心房肌细胞凋亡、心房结构和功能出现不可逆改变导致心房颤动。血管紧张素Ⅱ（ AngⅡ）是肾素－血管紧张素系统的关键效应产物，血管紧张素转换酶是生成AngⅡ的关键酶，AngⅡ可诱导心肌细胞凋亡。高甲状腺素致心房颤动有多种机制，其中可能的机制之一是高甲状腺素增强血管紧张素转换酶的活性，激活肾素－血管紧张素系统，AngⅡ高表达，后者进一步促进心房肌细胞凋亡导致心房颤动。“,”Atrial structure and function incur irreversible damage during cardiomyocyte apoptosis.This leads to atrial fibrillation.An-giotensinⅡis a critical product of the renin-angiotensin system.The presence of the angiotensin-converting enzyme is the key to the produc-tion of angiotensinⅡ, and angiotensin Ⅱmay promote the apoptosis of cardiomyocytes.In turn, high thyroxine levels may lead to an in-crease in angiotensin-converting enzyme activity, which increases the production of angiotensinⅡ, thereby leading to atrial fibrillation.