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[目的]探讨p16基因在蒙古族宫颈癌中的表达与汉族是否存在差异及是否可作为宫颈癌的辅助诊断指标。[方法]采用免疫组织化学方法检测63例蒙古族宫颈癌和30例汉族宫颈癌p16基因的表达情况,同时取18例蒙古族和18例汉族正常宫颈组织作对照。[结果]蒙古族宫颈癌及正常宫颈组织中p16阳性表达率分别为82.54%、5.56%(χ2=36.68,P=0.00);汉族宫颈癌及正常宫颈组织中p16阳性表达率分别为96.67%、11.11%(χ2=36.00,P=0.00);蒙古族宫颈癌与汉族子宫颈癌及两民族正常宫颈组织分别相比,p16表达无差异(χ2=2.46,P=0.12)。[结论]p16基因在蒙汉族宫颈癌中的表达无差异。
[Objective] To investigate whether p16 gene is differentially expressed in Mongolian patients with cervical cancer and whether it can be used as an auxiliary diagnostic indicator of cervical cancer. [Methods] The expression of p16 gene in 63 cases of Mongolian cervical cancer and 30 cases of cervical cancer in Han nationality was detected by immunohistochemical method. At the same time, 18 cases of Mongolian and 18 cases of normal cervical tissue were used as controls. [Results] The positive expression rates of p16 in Mongolian cervical cancer and normal cervical tissues were 82.54% and 5.56%, respectively (χ2 = 36.68, P = 0.00). The positive rates of p16 expression in cervical cancer and normal cervical tissue of Han nationality were 96.67% 11.11% (χ2 = 36.00, P = 0.00). There was no difference in the expression of p16 between Mongolian cervical cancer and Han nationality cervical cancer and normal cervical tissues (χ2 = 2.46, P = 0.12). [Conclusion] There is no difference in the expression of p16 gene in Mongolian and Han nationality cervical cancer.