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目的 :本着WHO提出 2 0 0 0年使癌症患者无疼的奋斗目标 ,努力寻找一个对癌痛治疗有效、合理、安全可靠、简单方便 ,易于基层掌握推广的止疼药和方法。方法 :选择 30例晚期癌痛病人 ,随机分成两组 ,每组各 1 5例 ,Ⅰ组用痛力克 1 0mg ,Ⅱ组用吗啡 2mg ,共同复合等量 5 0 %甘油和 0 75 %丁哌卡因 ,总量共 4ml,注入硬膜外腔止疼 ,观察两组药物止疼起效时间 ,止疼维持时间 ,镇痛效果 ,运动障碍情况及副作用。结果 :两组药在止疼起效时间平均 :Ⅰ组是 1 0 33± 1 .88min ,Ⅱ组是 9 93± 2 .0 2min ,总体P <0 0 1 ,组间比较 ΔP >0 0 5 ,患者个体间比较# P <0 0 5 ,说明P <0 0 1是因个体之间引起的 ,并非是两组药物间的差异 ;初次止疼平均时间 :Ⅰ组是 1 2 40± 1 72h ,Ⅱ组是 1 1 0 0± 0 5 3h ,P >0 0 5 ,ΔP >0 0 5 ,# P >0 0 5 ,提示两组药在初次止疼维持时间上无差异 ;再次给药平均止疼时间 ,Ⅰ组是 1 5 2 0± 4 79h ,Ⅱ组是 9 46± 1 5 9h ,P <0 0 1 ,ΔP <0 0 1 ,# P >0 0 5 ,P <0 0 1其差异是两组药物引起与个体无关 ;镇痛用VAS评估法 :Ⅰ组是 2 5 6 6± 0 2 88,Ⅱ组是 2 2 0± 0 2 96 ,P >0 0 5 ,ΔP >0 0 5 ,# P >0 0 5 ,两组药物在镇痛方面无差异。副作用方面 ,几乎全?
Objectives: In the spirit of WHO’s goal of making painless cancer patients in 2000, we are striving to find an effective and rational pain-relief medicine that is easy, safe, reliable, simple, and easy to grasp at the primary level. METHODS: Thirty patients with advanced cancer pain were randomly divided into two groups, each with 15 patients. Group I was treated with Dalcoca 10 mg, Group II was treated with morphine 2 mg, and a total of 50% of glycerol and 0.75% of Bupivae were jointly compounded. The total amount of cain, 4ml, was injected into the epidural space to stop the pain. The effect of onset of pain, duration of analgesia, analgesia, dyskinesia and side effects were observed in both groups. RESULTS: The onset time of pain relief in the two groups was average: group I was 1 0 33 ± 1 .88 min, group II was 9 93 ± 2. 0 2 min, overall P <0 01, group comparison ΔP> 0 0 5 ,P > 0.05 between patients, indicating that P <0 0 1 is caused by individuals, not the difference between the two groups of drugs; the average time of initial pain: I group is 1 2 40 ± 1 72h The group II was 1 1 0 0 ± 0 5 3h, P> 0 05, ΔP> 0 05, # P> 0 05, suggesting that there was no difference between the two groups in the time of initial pain maintenance; The analgesic time was 1520 ± 479h in group I and 9 46 ± 15h in group II, P <0 01, ΔP <0 01, # P> 0 05, P <0 0 1 The difference was that there was no relationship between the two groups of drug-induced individuals and VAS assessment of analgesia: group I was 2566.6 ± 0.288, group II was 2200 ± 0296, P> 0 05, ΔP> 0 0 5, # P >0 0 5 , there was no difference in pain relief between the two groups. In terms of side effects, almost all?