论文部分内容阅读
目的 :探讨头孢曲松钠联合苄星青霉素治疗快速血浆反应素(rapid plasma reagin,RPR)高滴度(≥1∶16)的妊娠梅毒患者的疗效。方法:回顾性分析本院诊治的RPR高滴度妊娠梅毒患者65例,根据治疗方法不同分为治疗组33例、对照组32例。其中治疗组给予头孢曲松钠联合苄星青霉素治疗,对照组给予苄星青霉素治疗,比较两组患者治疗后的临床效果和妊娠结局。结果:随访至治疗后的第12个月时,治疗组中妊娠梅毒患者有26例血清RPR转阴,痊愈率为78.79%;对照组中妊娠梅毒患者有17例血清RPR转阴,痊愈率为53.13%。两组妊娠梅毒痊愈率相比差异有统计学意义(P<0.05)。两组患者接受治疗后均未发生先天梅毒、死胎、低体重儿及新生儿死亡,对照组接受治疗后出现早产1例,妊娠结局无差异。结论:头孢曲松钠联合苄星青霉素治疗RPR高滴度妊娠梅毒效果较单一使用苄星青霉素显著,表现在血清RPR阴转时间缩短,转阴率高。
Objective: To investigate the efficacy of ceftriaxone sodium combined with benzathine penicillin in the treatment of pregnant patients with high titer (≥1:16) of rapid plasma reagin (RPR). Methods: A retrospective analysis of 65 patients with RPR high titer pregnancy syphilis diagnosed and treated in our hospital was divided into treatment group (33 cases) and control group (32 cases) according to different treatment methods. The treatment group was given ceftriaxone combined with benzathine penicillin, while the control group was given benzylpenicillin. The clinical effect and pregnancy outcome were compared between the two groups after treatment. Results: At the 12th month after treatment, 26 pregnant women with syphilis had negative serum RPR in the treatment group, the cure rate was 78.79%. In the control group, 17 pregnant women with syphilis had negative serum RPR, the cure rate was 53.13%. The cure rate of syphilis between the two groups was significantly different (P <0.05). No congenital syphilis, stillbirth, low birth weight infants and neonatal death occurred after treatment in both groups. One case of preterm birth was found in the control group after treatment, and there was no difference in pregnancy outcome. Conclusion: The effect of ceftriaxone sodium combined with benzathine penicillin on the treatment of syphilis with high titer of RPR is more pronounced than that of benzathine penicillin alone. The results showed that the serum RPR time was shortened and the rate of negative conversion was high.