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探讨谷胱甘肽－S转移酶（GSR）和γ－谷氨酰转肽酶（γ－CT）与食管癌、胃癌及结肠癌发病的关系及其临床意义。方法：用生化方法测定35例食管癌、65例胃癌、26例结肠癌、34例胃炎伴癌前病变患者血清、癌组织、胃窦粘膜及胃癌癌旁粘膜中GST，γ－GT活性和25例胃癌术前及术后10天血清中该两种酶的活性。结果：食管瘤、胃癌、结肠癌患者血清及癌组织中GST、γ－GT活性明显高于各对照组（P＜0．01～0．005）；胃炎伴癌前病变患者血清及组织中GST、γ－GT活性虽高于对照组，但除组织中GST（P＜0．05）外，两组间差异无显著性。胃癌组织中该两种酶的活性明显高于胃炎伴癌前病变（P＜0．01）；胃癌组织中GST,γGT活性明显高于癌旁组织（P＜0．05），癌旁组织中该两种酶的活性又明显高于正常组织（P＜0．025）；胃癌术后10天血清中GST，γ－CT活性明显低于术前（P＜0．001）。结论：血清和组织中GST、γ－GT活性的测定可用于消化道恶性肿瘤高危人群的筛选，监测癌前病变的进展及预测肿瘤是否复发。
To investigate the relationship between glutathione-S transferase (GSR) and γ-glutamyl transpeptidase (γ-CT) and the pathogenesis of esophageal cancer, gastric cancer and colon cancer and its clinical significance. METHODS: GST, γ-GT activity and 25 serum samples from 35 patients with esophageal cancer, 65 patients with gastric cancer, 26 patients with colon cancer, 34 patients with gastritis precancerous lesions, serum, cancer tissue, antral mucosa, and gastric cancer adjacent mucosa were measured by biochemical methods. The activity of these two enzymes was measured in serum before and 10 days after surgery. Results: The activity of GST and γ-GT in serum and cancer tissues of esophageal cancer, gastric cancer, colon cancer were significantly higher than those in the control group (P<0.01-0.005); GST in serum and tissues of patients with gastritis precancerous lesions The activity of γ-GT was higher than that of the control group, but there was no significant difference between the two groups except GST (P<0.05). The activity of these two enzymes in gastric cancer tissues was significantly higher than that in gastritis with precancerous lesions (P<0.01); the activity of GST and γGT in gastric cancer tissues was significantly higher than that in adjacent tissues (P<0.05). The activity of these two enzymes was significantly higher than that of normal tissues (P<0.025); GST and γ-CT activity in serum at 10 days after gastric cancer were significantly lower than before surgery (P<0.001). Conclusion: The determination of GST and γ-GT activity in serum and tissues can be used to screen high-risk groups of gastrointestinal cancers, monitor the progression of precancerous lesions and predict whether the tumors relapse.