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目的：临床观察甲孕酮改善化疗患者的毒副反应。方法：对２０例恶性肿瘤化疗患者与加用甲孕酮化疗的２０例恶性肿瘤患者进行对比研究。结果：化疗＋甲孕酮组食量增加１６例（８０％），体重增加１５例（７５％），平均增加３ｋｇ。在６０个化疗周期中，白细胞下降Ⅲ。以上有１２个周期，占整个化疗周期的２０％。而单纯化疗组食量增加４例占（２０％），体重增加４例（２０％），白细胞下降Ⅲ。以上有３７个周期，占整个化疗周期的５３．３％。两组对比有显著性差异（Ｐ＜０．０１）。结论：甲孕酮能改善化疗患者饮食、增加体重、保护骨髓。
Objective: Clinical observation of medroxyprogesterone improves the toxicity of chemotherapy patients. Methods: A comparative study of 20 patients with chemotherapy for malignant tumors and 20 patients with malignant tumors treated with medroxyprogesterone was conducted. Results: In the chemotherapy + medroxyprogesterone group, food intake increased by 16 cases (80%), weight gain was 15 cases (75%), and the average increase was 3 kg. In 60 cycles of chemotherapy, leukocytes decreased by III. There are 12 cycles above, accounting for 20% of the entire chemotherapy cycle. In the chemotherapy-only group, food intake increased in 4 cases (20%), weight gain in 4 cases (20%), and leukopenia decreased. There were 37 cycles above, accounting for 53.3% of the entire chemotherapy cycle. There was a significant difference between the two groups (P<0.01). Conclusion: Megestrol can improve the diet, weight gain and bone marrow protection of chemotherapy patients.