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本文使用动脉夹阻断局部血流以速成肿瘤乏氧的方法来研究探讨Ig7611对小鼠乳腺癌乏氧细胞的放射增敏作用。结果,Iq7611对乏氧肿瘤得到敏增比(SER)值为1.3,不乏氧肿瘤敏增比为1.1,前者大于后者。Iq7611对小鼠正常皮肤无增敏作用。该结果提示Iq7611可能具有选择性地增加小鼠肿瘤乏氧细胞放射敏感性的作用。
This article uses the arterial clip to block the local blood flow to accelerate tumor hypoxia to investigate the radiosensitizing effect of Ig7611 on murine breast cancer hypoxic cells. As a result, Iq7611 had a sensitivity increase ratio (SER) value of 1.3 for hypoxic tumors, and the oxygen sensitivity ratio of oxygen tumor was 1.1. The former was greater than the latter. Iq7611 has no sensitizing effect on normal skin of mice. This result suggests that Iq7611 may selectively increase the radiosensitivity of mouse tumor hypoxic cells.