组织型纤维蛋白溶酶原激活剂(t-PA)常常能使堵塞的血管发生部分甚至完全再通。与尿激酶和链激酶不同,t-PA 不会引起全身抗凝作用。因此,在急性闭塞性卒中治疗中使用 t-PA 引起出血并发症的可能性不大。本研究的目的在于探讨兔脑栓塞后 1h或2h 使用 t-PA 是否能缩小缺血脑组织的体积,并研究同时使用肝素的效果。用体重为3kg 的白兔35只,随机分为7组。向 Tissue plasminogen activator (t-PA) can often partially or completely block blocked blood vessels. Unlike urokinase and streptokinase, t-PA does not cause systemic anticoagulation. Therefore, the use of t-PA in the treatment of acute obstructive stroke is unlikely to cause bleeding complications. The aim of this study was to investigate whether t-PA can reduce the volume of ischemic brain tissue at 1 or 2 h after cerebral embolism and to study the effect of concurrent use of heparin. 35 rabbits weighing 3 kg were randomly divided into 7 groups. to