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目的:探讨血清CA125、EmAb与不同部位子宫内膜异位症(EM)之间的相关性。方法:选择经手术或腹腔镜确诊的EM患者96例和排除EM的对照组40例,按EM发生部位的不同分为3组:A组卵巢EM组42例;B组盆腔EM组40例,发生部位:子宫表面、膀胱腹膜反折、宫骶韧带及阔韧带;C组腹壁切口EM组14例。D组为对照组,40例,系为临床和病理检查排除了EM者。用酶联免疫吸附法(ELISA法)检测CA125及EmAb。结果:卵巢EM组血清CA125水平显著高于对照组(P<0.05),盆腔及腹壁切口EM组CA125水平明显低于卵巢EM组(P<0.05),而这两组间比较无统计学意义(P>0.05);以血清CA125≥35 kU/L为阳性判断标准,CA125及EmAb诊断各组EM的敏感性分别为:卵巢EM组69.04%、45.23%,盆腔45.00%、32.50%,腹壁切口EM组42.85%、28.57%;诊断的特异性分别为95%、97.5%;当两项指标均为阳性时,诊断EM的特异性为100%。结论:CA125及EmAb在诊断EM发生方面具有一定的价值,联合运用血清CA125和EmAb检测对EM诊断有较好的特异性。
Objective: To investigate the correlation between serum CA125, EmAb and different parts of endometriosis (EM). Methods: Ninety-six EM patients diagnosed by operation or laparoscopy and 40 control patients without EM were divided into three groups according to the location of EM: 42 cases in group A ovarian EM; 40 cases in group B, Occurring sites: uterine surface, bladder peritoneal reflex, uterosacral ligaments and broad ligament; C group 14 cases of abdominal incision EM group. D group as the control group, 40 cases, for clinical and pathological examination excluded EM. CA125 and EmAb were detected by enzyme-linked immunosorbent assay (ELISA). Results: The level of serum CA125 in ovarian EM group was significantly higher than that in control group (P <0.05). The level of CA125 in pelvic and abdominal wall EM group was significantly lower than that in ovary EM group (P <0.05), but there was no significant difference between the two groups P> 0.05). The sensitivity of CA125 and EmAb in diagnosing EM in each group were 69.04%, 45.23%, 45.00%, 32.50% in ovarian EM group, respectively. The positive rate of serum CA125≥35 kU / 42.85% and 28.57% respectively. The specificity of diagnosis was 95% and 97.5% respectively. When both indexes were positive, the specificity of diagnosis of EM was 100%. Conclusion: CA125 and EmAb have some value in the diagnosis of EM. Combined use of serum CA125 and EmAb detection has good specificity for the diagnosis of EM.