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作者以往进行的动物试验表明,腹腔内注射人免疫球蛋白可纠正化疗或放射所致的肠道菌群失调.本文研究人免疫球蛋白对非特异性溃疡性结肠炎(以下称溃结)患者大肠内菌丛的影响.共观察41例溃结患者,年龄20～50岁.溃结的诊断根据为临床、X线和内镜资料.受检者分为两个病情严重度相同的组.实验组29名患者,对照组12例.所有患者均给予镇静剂、解痉剂和维生素类.此外,实验组患者肌注含有对大肠杆菌014抗体的人免疫球蛋白,每次15ml,间隔48小时,共3次;对照组则以皮质激素和偶氮磺胺吡啶代替免疫球蛋白.治疗前(第零天)和完成疗程后(第7天)作直肠乙状结肠镜检观察结肠粘膜状态,同时测定结肠内菌丛.在进行菌丛研究时,按治疗前微生物数量的不同,把实验组和对照组患者又分为3个亚组,每克粪便所含菌体数分别为10~6～10~7、10~8和10~9.
Previous animal experiments conducted by the authors showed that intraperitoneal injection of human immunoglobulin can correct the imbalance of intestinal microflora caused by chemotherapy or radiation.This study investigated the effect of human immunoglobulin on the large intestine of patients with nonspecific ulcerative colitis 41 bacterial ulceration patients were observed, aged from 20 to 50. The diagnosis of ulceration was based on clinical, X-ray and endoscopic data.The subjects were divided into two groups with the same severity.The experiment 29 patients in the control group, 12 patients in the control group.All patients were given sedatives, antispasmodic agents and vitamins.In addition, the experimental group of patients intramuscular injection of human immunoglobulin against E. coli 014 antibody, each 15ml, 48 hours apart, A total of 3 times; the control group was replaced by corticosteroids and sulfasalazine immunoglobulin before treatment (day 0) and after completion of treatment (day 7) for colon sigmoid colonoscopy observed colonic mucosa state, while the determination of intra-colon In the study of bacterial flora, according to the number of microorganisms before treatment, the experimental and control patients were divided into three subgroups, the number of bacteria per gram of stool was 10 ~ 6 ~ 10 ~ 7 , 10 ~ 8 and 10 ~ 9.