肥胖是全球最常见的流行病之一 ,常并发 2型糖尿病、高血压以及脂代谢紊乱等代谢疾病。研究表明 ,肥胖尤其是内脏型肥胖是引发胰岛素抵抗 (ＩＲ)的主要因素 ,而ＩＲ则是糖尿病、高血压及脂代谢紊乱发生的基础。肥胖引起ＩＲ的机制仍然是一个尚未明确的课题。随着对ＩＲ认识的深 Obesity is one of the most common epidemics in the world and is often associated with metabolic diseases such as type 2 diabetes, hypertension and dyslipidemia. Studies have shown that obesity, especially visceral obesity, is a major cause of insulin resistance (IR), and IR is the basis of diabetes, hypertension and lipid metabolism disorders. The mechanism by which IR causes obesity remains an open issue. With the deep understanding of IR