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目的探讨小剂量尿激酶治疗急性脑梗死的疗效。方法将80例急性脑梗死患者随机分为对照组和治疗组各40例。对照组应用丹参川芎嗪10ml加入生理盐水或5%葡萄糖200ml静滴,1次/d,14d为1个疗程,且根据患者情况给予脱水降颅压、降压、降糖、降脂及改善循环、清除自由基等治疗。治疗组在对照组基础上加用尿激酶20万U,连续静滴3d。观察治疗效果及神经系统功能恢复情况。结果治疗组的基本痊愈及总有效率明显高于对照组,差异具有统计学意义(P<0.05);对照组治疗前后神经功能缺损及生活能力状态评分比较,差异具有统计学意义(P均<0.05);治疗组的神经功能缺损评分及生活能力状态评分治疗前后对比差异有统计学意义(P<0.01)。结论小剂量尿激酶静脉溶栓治疗急性脑梗死疗效显著,改善预后,适用于基层医院推广。
Objective To investigate the efficacy of low-dose urokinase in the treatment of acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly divided into control group and treatment group, 40 cases each. The control group was treated with 10ml Salvia miltiorrhizae ligustrazine or normal saline or dextrose 5% dextrose 200ml intravenously once a day for 14 days for one course of treatment. Dehydration was used to reduce intracranial pressure, blood pressure, hypoglycemic, lipid-lowering and circulation improvement , Remove free radicals and other treatment. Treatment group in the control group based on the addition of urokinase 20 million U, intravenous infusion of 3d. To observe the therapeutic effect and recovery of nervous system function. Results The basic cure rate and total effective rate in the treatment group were significantly higher than those in the control group (P <0.05). There was significant difference between the control group before and after the neurological deficit and the living status score (P < 0.05). There was significant difference between the treatment group before and after the neurological deficit score and the life status score (P <0.01). Conclusion Low-dose urokinase intravenous thrombolytic therapy for acute cerebral infarction significant effect, improve prognosis, suitable for promotion of primary hospital.