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目的:观察米非司酮对宫内膜雌激素受体(ER)及孕激素受体(PR)远期损害的影响。方法:选择36例既往有服用米非司酮紧急避孕史患者(A组),24例既往有服用米非司酮流产史患者(B组),30例既往有早期妊娠行人工流产病史的患者(C组),3组患者均有不同程度的月经量减少。患者就诊后记录其月经量改变情况,检测其血清性激素水平以及子宫内膜雌激素受体、孕激素受体表达强度。对3组结果进行统计学分析。结果:3组患者血清性激素水平比较无统计学意义,P>0.05。ER在A组中的表达分别比在B、C两组中的表达弱,差异有统计学意义,P<0.05;而在B、C两组比较差异无统计学意义,P>0.05。PR在3组中的表达情况与ER相同。在A、B、C 3组内分别做比较,ER、PR的表达强度在同一组内的差异无统计学意义,P>0.05。结论:推测大剂量服用米非司酮引起月经减少,可能与ER、PR表达下降、子宫内膜损害有关。
Objective: To observe the effect of mifepristone on the long-term damage of endometrial estrogen receptor (ER) and progesterone receptor (PR). Methods: Thirty-six patients (Group A) with previous history of mifepristone emergency contraception, 24 patients previously treated with mifepristone (Group B), and 30 patients with previous history of induced abortion (C group), 3 groups of patients have different degrees of menstrual decrease. After the patient was treated, the changes of menstrual flow were recorded, and the level of serum sex hormone and the expression of estrogen receptor and progesterone receptor in the endometrium were detected. Three groups of results were statistically analyzed. Results: There was no significant difference in serum sex hormone levels between the three groups (P> 0.05). The expression of ER in group A was weaker than that in group B and C, respectively, the difference was statistically significant (P <0.05); while there was no significant difference in group B and C (P> 0.05). The expression of PR in the three groups was the same as that of ER. There were no significant differences in the expression intensity of ER and PR in the same group between A, B and C groups (P> 0.05). Conclusion: It is speculated that high dose of mifepristone may reduce menstruation, which may be related to the decrease of ER and PR expression and the damage of endometrium.