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目的观察阿托伐他汀联合通心络胶囊治疗急性脑梗死(ACI)的临床效果。方法将240例ACI患者随机分为A组和B组和C组各80例。A组采用阿托伐他汀联合通心络胶囊治疗。B组采用通心络胶囊治疗。C组采用阿托伐他汀治疗。比较3组临床疗效和不良反应发生情况。比较3组治疗前后血清血管内皮细胞生长因子(VEGF)和超敏C反应蛋白(hs-CRP)水平。比较3组治疗前和治疗后1、3、6个月的神经功能缺损(NIHSS)评分和日常生活活动能力(Barthel)评分。结果 A组总有效率高于B组和C组(P<0.05)。治疗后第1、3、6个月,3组NIHSS评分低于治疗前,Barthel评分高于治疗前,且A组波动幅度大于B、C组(P<0.05)。治疗后3组VEGF水平升高,hsCRP水平降低,且A组波动幅度大于B组和C组(P<0.05)。结论阿托伐他汀联合通心络胶囊治疗急性脑梗死,可明显降低患者炎性反应水平,促进患者新生血管形成,改善患者神经功能缺损,提高患者的生活质量,疗效优于单用阿托伐他汀和通心络胶囊,具有较好的社会经济效益,值得临床推广应用。
Objective To observe the clinical effect of atorvastatin combined with Tongxinluo capsule in the treatment of acute cerebral infarction (ACI). Methods 240 patients with ACI were randomly divided into A group and B group and C group 80 cases. Group A was treated with atorvastatin combined with Tongxinluo capsule. Group B Tongxinluo capsule treatment. Group C was treated with atorvastatin. The clinical efficacy and adverse reactions of the three groups were compared. The levels of serum vascular endothelial growth factor (VEGF) and high-sensitivity C-reactive protein (hs-CRP) in the three groups before and after treatment were compared. The NIHSS scores and Barthel scores were compared between the three groups before treatment and at 1, 3, and 6 months after treatment. Results The total effective rate of group A was higher than that of group B and C (P <0.05). At 1, 3 and 6 months after treatment, the NIHSS scores of three groups were lower than those before treatment, Barthel score was higher than before treatment, and the fluctuation of group A was greater than that of group B and C (P <0.05). After treatment, the level of VEGF increased and the level of hsCRP decreased in group 3, and the fluctuation in group A was greater than those in group B and C (P <0.05). Conclusions Atorvastatin combined with Tongxinluo Capsule in the treatment of acute cerebral infarction can significantly reduce the level of inflammatory response in patients, promote neovascularization in patients, improve neurological deficits and improve the quality of life of patients with better curative effect than atorvastatin alone Statins and Tongxinluo capsules, has a good social and economic benefits, it is worth promoting the clinical application.