目的　研究血栓调节蛋白在成人肺组织及胎肺组织中的表达意义。　方法　以发育 18周的人胎肺组织、正常成人肺组织为研究对象 ,应用免疫组织化学 SP法检测血栓调节蛋白的存在。　结果　在 18周人胎肺组织中 ,血栓调节蛋白表达于围绕原始肺泡上皮细胞团周围的血管内皮细胞中 ,在原始肺泡上皮细胞及原始支气管上皮细胞、软骨均呈阴性表达。正常成人肺组织内的血管内皮细胞呈阳性表达。　结论　血栓调节蛋白在人胎中期肺组织中未见表达。 Objective To study the expression of thrombomodulin in adult lung and fetal lung tissues. Methods Human fetal lung tissue and normal adult lung tissue were used as research objects. The immunohistochemical SP method was used to detect the existence of thrombomodulin. Results In 18-week-old human fetal lung tissue, thrombomodulin was expressed in the vascular endothelial cells around the primary alveolar epithelial cells, and was negative in the primary alveolar epithelial cells and the primary bronchial epithelial cells. Normal adult lung tissue within the vascular endothelial cells were positive. Conclusion Thrombomodulin is not expressed in metaphase lung tissue.