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胃复安(灭吐灵)为胃肠系统疾病常用的止吐药物,在肿瘤化疗中常用以减轻化疗药物引起的恶心、呕吐胃肠道副反应,保证化疗顺利进行,但胃复安用量较大,易引起锥体外系症状的副作用。近10年我院共发现化疗患者出现锥体外系症状30例,现分析如下。 1 临床资料 1.1 一般资料 30例患者均为本院病人,其中男性13例,女性17例;年龄1～70岁,平均年龄41.2岁。30例化疗患者既往无神经系统病史,在化疗中使用胃复安后才出现锥体外系症状,停服此药或使用费定后,锥体外系症状消失。
Metoclopramide is an antiemetic drug commonly used for gastrointestinal diseases. It is commonly used in chemotherapy for cancer to reduce the gastrointestinal side effects of nausea and vomiting caused by chemotherapeutic drugs, and to ensure the smooth progress of chemotherapy, but the amount of metoclopramide is more effective. Large, easy to cause side effects of extrapyramidal symptoms. In the past 10 years, a total of 30 cases of extrapyramidal symptoms in patients diagnosed with chemotherapy in our hospital have been analyzed as follows. 1 Clinical data 1.1 General information 30 patients were hospital patients, including 13 males and 17 females; aged 1 to 70 years, mean age 41.2 years. Thirty patients with chemotherapy had no previous history of neurological disease. After using metoclopramide for chemotherapy, extrapyramidal symptoms appeared. After taking the drug or setting prescription, extrapyramidal symptoms disappeared.