维生素A是人和动物为维持正常的生理功能而必须从食物中获取的一类微量有机物质。全反式维甲酸是维生素A的一种活性代谢物,它不仅调控固有免疫反应中的巨噬细胞、树突细胞和固有淋巴样细胞的功能,而且也调控获得性免疫反应中的T细胞和B细胞的功能,从而在免疫稳态中发挥重要作用。本文主要综述近年来全反式维甲酸对巨噬细胞、树突细胞、固有淋巴样细胞以及淋巴细胞调控的研究进展。 Vitamin A is a trace of organic matter that humans and animals must obtain from food in order to maintain normal physiological functions. All-trans retinoic acid, an active metabolite of vitamin A, not only regulates the function of macrophages, dendritic cells and innate lymphoid cells in innate immune responses, but also regulates T cells in adaptive immune responses and B cell function, which plays an important role in immune homeostasis. This review summarizes the recent progress in the regulation of macrophages, dendritic cells, innate lymphoid cells, and lymphocytes by all-trans retinoic acid.