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目的 建立冲击波负压听器创伤动物模型 ,并评价其稳定性和实用性。方法 将豚鼠置于冲击波负压发生装置的动物舱内 ,观察并分析不同条件下实验性冲击波负压的主要物理参数及豚鼠听觉器官形态和功能变化。结果 共采集和分析 12 6次冲击波负压信号 ,各次波形均呈典型的负压指数曲线 ,负压峰值范围为 15 .6～ 87.2kPa ,降压时间介于 3.0 5 0～ 15 .175ms之间。通过 16 4只豚鼠 318耳的观察 ,发现不同强度冲击波负压暴露后 ,中耳、内耳的形态结构和听功能发生了不同程度的创伤或损害 ,且具有良好的稳定性和重复性。结论 应用冲击波负压发生装置 ,建立了稳定的豚鼠听器冲击波负压创伤模型 ,为进一步开展听器冲击波负压创伤的有关研究奠定了良好基础
Objective To establish a shock animal model of negative pressure hearing aids and to evaluate its stability and practicability. Methods The guinea pigs were placed in the animal compartment of shock negative pressure generating device. The main physical parameters of shock wave negative pressure and the morphological and functional changes of guinea pig auditory organs under different conditions were observed and analyzed. Results A total of 12 6 shock negative pressure signals were collected and analyzed. Each waveform showed a typical negative pressure exponential curve. The negative pressure peak ranged from 15.6 to 87.2 kPa, and the step-down time ranged from 3.05 to 15.175 ms between. Through the observation of 318 guinea pigs with 168 ears, it was found that under the negative pressure of shock waves with different intensities, the morphological structure and hearing function of middle ear and inner ear had different degree of trauma or damage, and had good stability and repeatability. Conclusion The shock wave negative pressure trauma model of guinea pig’s hearing aids was established by using the shock negative pressure generating device, which laid a good foundation for the further research on the negative pressure trauma of the hearing impulse wave